The proliferation index, employing a novel cell proliferation marker ipo. The aim of the present study was to compare the proliferation index of the epithelial cells between odontogenic keratocysts okc, orthokeratinized odontogenic cysts ooc, dentigerous cysts dc, and ameloblastomas. Clinically, it presents no tendency to relapse due to low local aggressiveness, and is not associated with the nevoid basal cell carcinoma syndrome nbccs. A clinical diagnosis of ameloblastoma or odontogenic keratocystic tumor was established. In order to highlight the malignant potential of ooc, especially in patients with a history of recurrence and inflammation, we describe a rare case of recurrent ooc that transformed into squamous cell carcinoma after. Orthokeratinized odontogenic cyst ooc is a rare, developmental odontogenic cyst which was considered in the past to be a variant of keratocystic odontogenic tumor kcot. Orthokeratinized odontogenic cyst ooc is a rare intraosseous cyst characterized by an orthokeratinized epithelial lining and minimal clinical aggressiveness. Pdf immunohistochemical study of the orthokeratinized. Orthokeratinized odontogenic cyst is a specific type of keratinized odontogenic cysts which is completely different from keratocystic odontogenic. Orthokeratinized odontogenic cyst sarita yanduri et, al fig 1.
The 2005 edition reclassified the parakeratotic type as a keratocystic odontogenic tumour kcot and stated cystic jaw lesions that are lined by orthokeratinizing. Orthokeratinized odontogenic cyst of the mandible with. Oocs were first described in 1927 by schultz 2 as a variant of odontogenic keratocysts, now known as keratocystic odontogenic. Unusual aggressive presentation of orthokeratinized. The lesion has been termed variously as an orthokeratinized variant of okc. Orthokeratinized odontogenic cyst critical appraisal.
Synchronization of calcifying odontogenic cyst and. Orthokeratinized variant of odontogenic keratocyst. Recognition of ooc as a unique entity is of utmost importance as it bears resemblance to dentigerous cyst, and odontogenic keratocyst okc. The orthokeratinizing odontogenic cyst is considered an unrelated entity without risk of recurrence or aggressive growth or association with nevoid basal cell carcinoma syndrome. The suggestive etiology for okc is either from epithelial remnants of tooth germ in the mandible and maxilla or the. Pdf on may 1, 2012, niharika swain and others published orthokeratinized odontogenic cyst find, read and cite all the research you need. The orthokeratinized odontogenic cyst ooc is a rare developmental jaw cyst.
Orthokeratinized odontogenic cyst ooc is a rare, developmental odontogenic cyst which was considered in the past to be a variant of odontogenic keratocyst okc later renamed as keratocystic odontogenic tumor kcot. Orthokeratinized odontogenic cyst ooc is a relatively uncommon developmental cyst of the jaw constituting about 10%. However, other less common lesions, such as orthokeratinized odontogenic cysts oocs, can be found at this region, and they deserve to be discussed because the prognosis for an ooc is different from that expected for the ordinary inflammatory periapical diseases. Orthokeratinized odontogenic cyst with an associated keratocystic odontogenic tumor component and ghost cell keratinization and calcifications in a patient with gardner syndrome. Recognition of ooc as a unique entity is of utmost importance as it bears. The orthokeratinized odontogenic cyst ooc is a quite uncommon cyst of developmental odontogenic cyst. However, in 2017, the original classification was reused, it was designated that they are odontogenic developmental cysts, the odontogenic keratocyst and orthokeratinized odontogenic cyst being different entities and both defined as cysts. Odontogenic keratocyst was designated as keratocystic odontogenic tumor kcot in the new world health organization classification and ooc should be distinguished from kcot for differences in histologic features and. Orthokeratinized odontogenic cyst ooc is a rare developmental jaw cyst, considered as distinct entity from odontogenic keratocysts as it exhibits a less aggressive behaviour and a very low rate of recurrence. Pdf orthokeratinized odontogenic cyst researchgate.
Introduction the orthokeratinized odontogenic cyst ooc is a quite uncommon cyst of developmental odontogenic cyst. The orthokeratinized odontogenic cyst is a relatively rare developmental odontogenic cyst of the jaws that occurs predominantly in males between the third and fourth decades. The treatment of ooc is by enucleation and the prognosis, following enucleation is excellent with a recurrence rate of less than 2%. Jul, 2018 orthokeratinized odontogenic cyst ooc is a rare intraosseous cyst characterized by an orthokeratinized epithelial lining and minimal clinical aggressiveness. Orthokeratinized odontogenic cyst of the maxilla turkish journal. Odontogenic cysts, odontogenic tumors, fibroosseous, and.
Orthokeratinized odontogenic cyst ooc is an odontogenic cyst was initially termed as the uncommon orthokeratinized type of odontogenic keratocyst by the world health organization. Synchronization of calcifying odontogenic cyst and aneurysmal bone cyst. The calcifying odontogenic cyst coc is an uncommon odontogenic lesion with a somewhat wide spectrum of histologic features. Because the lesion sometimes appears as a solid noncystic lesion, referred to as odontogenic ghost cell tumor, it is no longer classified as one of the odontogenic cysts. Its incidence varies among different series, ranging from 16. Infected orthokeratinized odontogenic cyst 615 cyst is relatively rare 3,7. Orthokeratinized odontogenic cyst with an associated.
The present lesion likely represents a previously undescribed, histologic hybrid consisting of orthokeratinized odontogenic cyst and cartilaginous heterotopia. Odontogenic cysts, odontogenic tumors, fibroosseous. Chronic progression of recurrent orthokeratinized odontogenic. The orthokeratinized odontogenic cyst ooc was first identified by wright in 1981 as an individual entity distinct from other odontogenic cysts 1. Intraosseous jaw cysts with a solely orthokeratinized lining epithelium have been suggested to differ from the typical odontogenic keratocysts okc by exhibiting a less aggressive behaviour. A keratocystic odontogenic tumor kot formerly known as an odontogenic keratocyst is a benign cystic tumor of dental origin that probably arises from primitive dental lamina, most commonly occurs in the posterior mandible, and almost certainly represents the lesion that used to be known as a primordial cyst. Orthokeratinized odontogenic cyst ooc is a benign odontogenic cyst that rarely undergoes malignant transformation. Orthokeratinized odontogenic cyst ooc is a benign odontogenic cyst. Introduction calcifying odontogenic cyst coc or calcifying cystic odontogenic tumor ccot is one of the ghost cell odontogenic lesions that mostly grows as a cystic lesion. Pdf orthokeratinized odontogenic cyst of the maxilla. The treatment of ooc is by enucleation and the prognosis, following enucleation is excellent with a. Immunohistochemical study of the orthokeratinized odontogenic cyst. An abnormal space within tissue lined by epithelium.
Orthokeratinized odontogenic cysts presenting as a periapical. Orthokeratinized odontogenic cysts oocs are relatively uncommon developmental cysts lined with orthokeratinized epithelium consisting of a prominent granular layer and a basal layer of low cuboidal flattened cells that show no tendency for nuclear palisading. Orthokeratinized odontogenic cyst ooc is a relatively uncommon developmental cyst comprising about 10% of cases that had been previously coded as odontogenic keratocysts. The orthokeratinized odontogenic cyst may share some histologic features with okc but is orthokeratinized not parakeratinized and lacks the palisaded basal cell layer. Although both the first two editions of the world health organizations who histological classification of odontogenic tumours recognized that cases with. Odontogenic keratocyst was designated as keratocystic odontogenic tumor kcot in the new world health organization classification and ooc should be distinguished from kcot for differences in histologic features and biologic behavior. Is there justification for prophylactic extraction of third molars. Orthokeratinized odontogenic cyst with calcification. An aggressive orthokeratinized odontogenic cyst of the.
The histopathological examination showed bilateral orthokeratinized odontogenic cyst. A comparative study of epithelial cell proliferation between the odontogenic keratocyst, orthokeratinized odontogenic cyst, dentigerous cyst, and. Apr 28, 2009 a case presented is a 38yearold man with intraosseous keratinizing epidermoid cyst in the mandible, the wall of which contained a nodule of mature hyaline cartilage. Could be dermal metaplasia of an odontogenic cyst especially when found in association with a tooth or epithelial remnant. However, there is no statement concerning orthokeratinized okc in this version. Inflammatory cysts, granulomas, abscesses, and fibrous scars represent most periapical radiolucencies. In 1981, wright identified it, owing to its different histology and relatively low recurrence rate, as orthokeratinized variant of odontogenic keratocyst okc. The aim of the present study was to compare the proliferation index of the epithelial cells between odontogenic keratocysts okc, orthokeratinized odontogenic cysts ooc, dentigerous. Clinical study of keratocystic odontogenic tumor and. A comparative study of epithelial cell proliferation. The orthokeratinized odontogenic cyst ooc is a developmental odontogenic cyst relatively rare, arising from the cell rests of the dental lamina.
To describe the behavior clinical and pathological features of two cases of odontogenic cyst orthokeratinized. Unusual aggressive presentation of orthokeratinized odontogenic. Orthokeratinized odontogenic cyst ooc is a relatively rare lesion of the jaws, mainly located in the posterior segment of the mandible. Most commonly occurs in mandibular molar and ramus region, rarely seen in maxilla and mandibular premolar area. Odontogenic keratocyst okc shows characteristics of tumor. It is a variant of the common odontogenic keratocyst okc. International journal of contemporary medicine surgery and radiology. Orthokeratinized odontogenic cyst ooc is a developmental cyst of odontogenic origin and was initially defined as the uncommon orthokeratinized variant of the odontogenic keratocyst okc, until the world health organizations whos classification in 2005, where it was separated from the keratocystic odontogenic tumor kcot. Orthokeratinized odontogenic cyst ooc is a developmental cyst that occurs mostly in the maxillary corpus, it was initially defined by the world health organization in 1992 as the uncommon orthokeratinized type of odontogenic keratocyst okc sciubba jj et al, 1999. A male preference has been reported for ooc, with a maletofemale ratio of 2. Recognition of ooc as a unique entity has long been due.
We report 15 cases of such cyst type under the term of orthokeratinized odontogenic cyst ooc and compared their clinical, histological and. Orthokeratinized odontogenic cyst ooc is a relatively uncommon developmental cyst comprising about 10% of cases that had been previously coded as odontogenic. Oocs were first described in 1927 by schultz 2asa variant of odontogenic keratocysts, now known as keratocystic odontogenic tumours kcots 3. Nov 18, 2019 orthokeratinized odontogenic cyst ooc is a relatively rare lesion of the jaws, mainly located in the posterior segment of the mandible. Orthokeratinized odontogenic cyst ooc of condylar head. In the histological classification of who in 2005, parakeratinized okc was classified as keratocystic odontogenic tumor kcot. In the past majority of the cases has been coded as either odontogenic. Orthokeratinized odontogenic cyst ooc has been considered as a type of odontogenic keratocyst okc. Oocs were first described in 1927 by schultz as a variant of odontogenic keratocysts, now known as keratocystic odontogenic tumours kcots.
A clinical diagnosis of bilateral dentigerous cyst dc was rended. Orthokeratinized odontogenic cyst ooc is a relatively uncommon developmental cyst comprising about 10% of cases that had been previously coded as odontogenic keratocysts okcs. The orthokeratinized odontogenic cyst ooc 1 was first clearly identified as an orthokeratinzed variant of the odontogenic keratocyst by wright in 1981 2 owing to its different histopathology and reduced likelihood to recur. In 1981, wright identified it, owing to its different histology and relatively low recurrence rate, as. Of note, a dentigerous cyst is, by definition, always associated with an unerupted tooth. Pdf the orthokeratinized odontogenic cyst ooc is a rare developmental jaw cyst. This case report describes a rare malignant transformation of ooc, with the aim of raising awareness of the malignant potential of ooc and distinguishing it from okc. According to the 2005 world health organizations classification. Orthokeratinized odontogenic cyst diagnostic pathology. Odontogenic cysts that can be problematic because of recurrence andor aggressive growth include odontogenic keratocyst okc, calcifying odontogenic cyst.
The databases searched were the pubmed interface of medline and lilacs. Aug 15, 2019 although orthokeratinized odontogenic cyst ooc was first described as early as in 1927 by schultz1, it was first considered to be a variant of okc. Radiographically, a radiolucent area with a radiopaque was observed. Orthokeratinized odontogenic cyst ooc is a rare intraosseous cyst characterized by an orthokeratinized epithelial lining and minimal clinical aggressiveness 1. Orthokeratinized odontogenic cyst ooc is also a developmental cyst occurring in the tooth bearing regions of jaws and is defined by the world health organisation as the uncommon orthokeratinized type of odontogenic keratocyst okc. Research orthokeratinized odontogenic cyst in a hong kong community.
The orthokeratinized odontogenic cyst was recognized as a variant of okc based on the presence of abundant orthokeratin in the cystic lining. Orthokeratinized odontogenic cyst ooc is an uncommon lesion of the jaws and represents 7%17% of all keratinizing jaw cysts. Odontogenic keratocyst okc is a developmental cyst of tooth origin with an aggressive behaviour including high recurrence rate. A comparative study of epithelial cell proliferation between. Recognition of ooc as a unique entity has long been due, yet its inexplicable radiographic presentation resembling dentigerous cyst, histological likeness to odontogenic keratocyst okc and inconsistent cytokeratin expression profiles overlapping with both as well as with the epidermis, makes it rather. Orthokeratinized odontogenic cyst adults no sex predilection unilocular or multilocular lining is orthokeratinized with a granular layer, rather than parakeratinized like okc low incidence of recurrence following curettage. A rare case report of orthokeratinized odontogenic. Orthokeratinized odontogenic cyst critical appraisal of a distinct entity ovi dental. Recognition of ooc as a unique entity has long been due, yet its inexplicable radiographic presentation resembling dentigerous cyst, histological likeness to odontogenic keratocyst okc and inconsistent cytokeratin expression profiles overlapping with both as well as with the epidermis, makes it rather confounding. This concept, independent of odontogenic developmental cyst, has been inherited by the who classification of head and neck tumours who 2, because of the many single cystic cases. Odontogenic keratocyst parakeratinized versus orthokeratinized. Surgical treatment of orthokeratinized odontogenic cyst in. In case 1, a 17yearold woman presented hard and painless swelling in the left posterior mandible.
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